Is the addition of sublingual melatonin to omeprazole superior to omeprazole alone in the management of gastroesophageal reflux disease symptoms: a clinical trial
Malekpour H, et al.
Published in Turkish Journal of Gastroenterology
Methodology
Randomized clinical trial comparing sublingual melatonin plus omeprazole with omeprazole alone for 4 weeks in GERD patients, using validated reflux symptom questionnaires.
Key Findings
Adding sublingual melatonin 3 mg to omeprazole 20 mg produced greater improvement in heartburn and regurgitation symptom scores over four weeks than omeprazole alone in patients with gastroesophageal reflux disease.
Conclusions
The combination of sublingual melatonin (3 mg/day) with omeprazole (20 mg/day) may be more effective than omeprazole (20 mg/day) alone in the treatment of gastroesophageal reflux disease.
Limitations
Modest single-centre sample (n=72), short duration, symptom-based endpoints without endoscopic or pH-metry confirmation, and limited blinding detail.
Supplements Studied
The combination of sublingual melatonin (3 mg/day) with omeprazole (20 mg/day) may be more effective than omeprazole (20 mg/day) alone in the treatment of gastroesophageal reflux disease.
Outcomes Measured
The present study aimed to investigate whether the addition of sublingual melatonin to omeprazole was effective in the treatment of gastroesophageal reflux disease symptoms.
Related Health Concerns
Study Details
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