Regression of gastroesophageal reflux disease symptoms using dietary supplementation with melatonin, vitamins and aminoacids: comparison with omeprazole

Pereira RS

Published in Journal of Pineal Research

Methodology

Randomized comparison of a melatonin-based dietary supplement versus omeprazole 20 mg daily in GERD patients over 40 days with structured symptom questionnaires

Key Findings

Complete regression of GERD symptoms occurred in 100 percent of the supplement group versus 65.7 percent of the omeprazole group

Conclusions

The melatonin-containing supplement relieved GERD symptoms more than omeprazole in this cohort

Limitations

Not placebo-controlled; unclear blinding; multi-ingredient formula; subjective outcomes; industry-linked author

Supplements Studied

Melatonin

Compound

Complete regression of GERD symptoms occurred in 100% of patients that used the dietary supplementation, and in 65.7% of the patients treated with omeprazole.