rct
    2011
    High Quality

    Resveratrol, AMPK activation and mTOR inhibition in humans: a randomized controlled trial

    Timmers S, Konings E, Bilet L, Houtkooper RH, van de Weijer T, Goossens GH

    Published in Cell Metabolism

    Methodology

    Randomized double-blind crossover trial of 30 days of resveratrol in obese men with muscle biopsies for AMPK, SIRT1 and mitochondrial signalling.

    Key Findings

    Resveratrol activated AMPK and increased SIRT1 and mitochondrial protein levels while lowering metabolic rate and inflammation markers.

    Conclusions

    Resveratrol induces calorie-restriction-like signalling that opposes mTOR-driven anabolic pathways.

    Limitations

    Small crossover sample; obese men only; short duration.

    Supplements Studied

    Resveratrol
    Compound

    Resveratrol activated AMPK and increased SIRT1 and mitochondrial protein levels

    Outcomes Measured

    mTOR Regulation

    Resveratrol activated AMPK and increased SIRT1 and mitochondrial protein levels

    White Fat Browning

    Resveratrol lowered sleeping and resting metabolic rate.

    AMPK Activation

    Resveratrol activated AMPK and increased SIRT1 and mitochondrial protein levels while lowering metabolic rate and inflammation markers.

    Sirtuin Activation

    Resveratrol activated AMPK and increased SIRT1 and mitochondrial protein levels while lowering metabolic rate and inflammation markers.

    Study Details

    Year:2011
    Sample Size:11
    Duration:4 weeks
    Quality Score:7/10

    Access Study

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