Effect of B-vitamins on stroke risk among individuals with vascular disease who are not on antiplatelets: A meta-analysis
Park JH, Saposnik G, Ovbiagele B, Markovic D
Published in International Journal of Stroke
Methodology
Systematic review and meta-analysis of randomized homocysteine-lowering trials (VISP, VITATOPS, HOPE-2) stratified by antiplatelet use, follow-up >= 1 year.
Key Findings
Among 4,643 high vascular risk subjects not taking antiplatelet medication, B-vitamin supplementation was associated with reduced subsequent stroke risk; benefit was not seen in those on antiplatelets.
Conclusions
Any cerebrovascular benefit of homocysteine lowering appears limited to patients not receiving antiplatelet therapy.
Limitations
Only three trials reported antiplatelet-stratified data; post-hoc subgroup analysis prone to confounding.
Supplements Studied
B-vitamin supplementation on risk of subsequent stroke among high cardiovascular risk individuals who are not taking antiplatelet medications
randomized controlled trials of homocysteine-lowering therapy with B-vitamins
Related Health Concerns
Study Details
Access Study
Disclosures
Funding
Not reported
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.