rct
    2013
    High Quality

    Effect of GutGard in the Management of Helicobacter pylori: A Randomized Double Blind Placebo Controlled Study

    Puram S, Suh HC, Kim SU, Bethapudi B, Joseph JA

    Published in Evidence-Based Complementary and Alternative Medicine

    Methodology

    Randomised, double-blind, placebo-controlled trial of 150 mg/day Glycyrrhiza glabra root extract (GutGard) versus placebo for 60 days in adults with confirmed H. pylori infection, assessed by 13C-urea breath test and stool antigen test

    Key Findings

    Licorice root extract significantly reduced H. pylori gastric load versus placebo over 60 days on breath-test measures.

    Conclusions

    A standardised licorice extract can lower H. pylori burden, supporting its traditional gastric use.

    Limitations

    Single-centre; manufacturer-linked authorship; surrogate load endpoints rather than eradication or symptoms.

    Supplements Studied

    A randomized, double blind placebo controlled study was conducted to evaluate the efficacy of GutGard (root extract of Glycyrrhiza glabra) in the management of Helicobacter pylori (H. pylori) gastric load.

    Outcomes Measured

    Heartburn Relief

    H. pylori infection was assessed using (13)C-urea breath test ((13)C-UBT) at days 0, 30, and 60.

    Gut Barrier Integrity
    Primary

    significant difference in mean Delta Over Baseline (DOB) values between GutGard (n = 50) and placebo (n = 50) treated groups after interv

    Study Details

    Year:2013
    Sample Size:107
    Duration:9 weeks
    Quality Score:7/10

    Access Study

    View on DOIView on PubMedOriginal Source

    Disclosures

    Funding

    Manufacturer-affiliated

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.