Magnesium for acute traumatic brain injury
Arango MF
Published in Cochrane Database of Systematic Reviews
Methodology
Cochrane systematic review of randomized controlled trials of magnesium salts versus placebo or control in patients with acute traumatic brain injury, with mortality and disability as primary outcomes.
Key Findings
Only two small randomized trials met inclusion criteria and neither showed benefit of magnesium salts on mortality or neurological outcome after acute traumatic brain injury; one suggested a possible trend towards harm.
Conclusions
No evidence supports the use of magnesium salts in acute traumatic brain injury.
Limitations
Very few eligible trials with small combined sample size, heterogeneous dosing regimens, and insufficient power to detect moderate treatment effects.
Supplements Studied
There is currently no evidence to support the use of magnesium salts in patients with acute traumatic brain injury.
Related Health Concerns
Study Details
Access Study
Disclosures
Funding
Cochrane Injuries Group; no commercial sponsorship reported.
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