Dietary Buglossoides arvensis oil increases circulating n-3 polyunsaturated fatty acids in a dose-dependent manner and enhances lipopolysaccharide-stimulated whole blood interleukin-10: a randomized placebo-controlled trial
Lefort N, LeBlanc R, Surette ME
Published in Nutrients
Methodology
Randomized, double-blind, placebo-controlled dose-ranging trial of Buglossoides arvensis oil (rich in ~20% stearidonic acid) in healthy adults, measuring plasma fatty acids and ex vivo cytokine responses.
Key Findings
Circulating n-3 fatty acids, particularly EPA and docosapentaenoic acid, rose in a dose-dependent manner. Lipopolysaccharide-stimulated whole blood interleukin-10 production increased, suggesting a modest immunomodulatory shift. No safety signals emerged.
Conclusions
Ahiflower oil dose-dependently raises n-3 status and produces measurable but preliminary immune-marker changes in healthy adults.
Limitations
Healthy volunteers only, short duration, ex vivo cytokine endpoints rather than clinical outcomes, and industry-supplied oil.
Supplements Studied
Circulating n-3 fatty acids rose dose-dependently and LPS-stimulated whole blood interleukin-10 production increased in healthy adults.
Study Details
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Disclosures
Funding
Bioriginal Food & Science / Ahiflower oil supplier provided study material.
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