The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Guo J, Chen H, Zhang X, Lou W, Zhang P, Qiu Y, Zhang C
Published in Oxidative Medicine and Cellular Longevity
Methodology
Systematic review and meta-analysis of 46 randomised trials (over 4000 participants) of berberine, alone or with hypoglycaemic drugs, in type 2 diabetes.
Key Findings
Berberine significantly reduced fasting plasma glucose, HbA1c, postprandial glucose, HOMA-IR, total cholesterol, LDL and triglycerides versus control, with mainly mild gastrointestinal side effects.
Conclusions
Berberine improves glycaemic and lipid profiles in type 2 diabetes, supporting the rationale for better-absorbed forms such as dihydroberberine.
Limitations
Most trials conducted in China with modest methodological quality; heterogeneity high; evidence is for berberine, not dihydroberberine specifically.
Supplements Studied
Berberine significantly reduced fasting plasma glucose, HbA1c, HOMA-IR, LDL and triglycerides versus control.
Berberine, the main active component of Rhizoma Coptidis, has been demonstrated to have the potential effect of hypoglycemia.
Outcomes Measured
Berberine significantly reduced total cholesterol, LDL and triglycerides versus control.
Berberine significantly reduced fasting plasma glucose, HbA1c, postprandial glucose, HOMA-IR, total cholesterol, LDL and triglycerides versus control, with mainly mild gastrointestinal side effects.
Berberine significantly reduced fasting plasma glucose, HbA1c and postprandial glucose versus control.
Related Health Concerns
Study Details
Access Study
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.