Coenzyme Q10 and Cardiovascular Diseases

Mortensen SA, Rosenfeldt F, Kumar A, Dolliner P, Filipiak KJ, Pella D, Alehagen U, Steurer G, Littarru GP

Published in Molecular Aspects of Medicine

Abstract

Review examining CoQ10's role in cardiovascular health, including effects on heart failure and vascular function.

Methodology

Review of the biochemistry of coenzyme Q10 and of clinical trial evidence in heart failure, hypertension, endothelial function and statin-associated muscle symptoms.

Key Findings

Myocardial CoQ10 levels are reduced in advanced heart failure and correlate with severity. Supplementation improved functional class and, in the Q-SYMBIO trial, major adverse cardiovascular events. Effects on blood pressure and endothelial function are modest, and evidence for statin-associated muscle symptoms is inconsistent.

Conclusions

CoQ10 has a plausible mechanistic and clinical rationale as an adjunct in chronic heart failure; evidence for other cardiovascular indications remains weaker and should not displace standard therapy.

Limitations

Non-systematic review by authors involved in CoQ10 trials; heterogeneous formulations and doses with differing bioavailability; several supporting trials small and industry-supported.