Effects of Exogenous Ketone Supplementation on Blood Glucose: A Systematic Review and Meta-analysis
Falkenhain K, Daraei A
Published in Advances in Nutrition
Methodology
Systematic review and meta-analysis of randomized trials of exogenous ketone esters and salts on blood ketones and glucose.
Key Findings
Exogenous ketones reliably raised circulating beta-hydroxybutyrate and modestly lowered blood glucose across trials.
Conclusions
Ketone supplements dependably induce acute ketosis; downstream metabolic benefits remain uncertain.
Limitations
Acute dosing studies dominate; few long-term outcomes.
Supplements Studied
Exogenous ketones reliably raised circulating beta-hydroxybutyrate across trials
Outcomes Measured
Exogenous ketones reliably raised circulating beta-hydroxybutyrate and modestly lowered blood glucose across trials
Study Details
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