rct
    2025

    Oral Supplementation with a New Hyaluronic Acid Matrix Ingredient Improves Skin Brightness, Hydration, Smoothness, and Roughness: Results from a Randomized, Double-Blinded, Placebo-Controlled Study

    Montero-Vilchez T, et al.

    Published in Dermatology and Therapy

    Methodology

    Randomized, double-blind, placebo-controlled trial in healthy women taking an oral hyaluronic acid matrix ingredient for 12 weeks, with corneometry and image-analysis measures of hydration, brightness, smoothness and roughness.

    Key Findings

    Twelve weeks of an oral hyaluronic acid matrix significantly improved instrument-measured skin hydration, brightness and smoothness and reduced roughness versus placebo in healthy women.

    Conclusions

    Oral hyaluronic acid improved skin hydration and smoothness in healthy women; no pruritus outcome was measured, so relevance to itch is indirect via dryness.

    Limitations

    Small sample (n=50), healthy female cohort only, industry-relevant ingredient testing, and no pruritus or clinical dermatological endpoint.

    Supplements Studied

    Daily supplementation with HAm effectively improves multiple aspects of skin health and appearance, suggesting its potential as a safe and beneficial antiaging ingredient.

    Outcomes Measured

    Twelve weeks of an oral hyaluronic acid matrix significantly improved instrument-measured skin hydration, brightness and smoothness and reduced roughness versus placebo in healthy women.

    Related Health Concerns

    Study Details

    Year:2025
    Sample Size:50
    Duration:12 weeks
    Quality Score:5/10

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.