Subclinical Thyroid Dysfunction and the Risk of Cognitive Decline: A Meta-Analysis of Prospective Cohort Studies
Carole Rieben, Daniel Segna, Bruno R. da Costa, Tinh-Hai Collet, Layal Chaker, Carole E. Aubert, Christine Baumgartner, Osvaldo P. Almeida, Eef Hogervorst, Douglas C. Bauer, Robin P. F. Dullaart, Nicolas Rodondi
Published in Journal of Clinical Endocrinology & Metabolism
Abstract
This meta-analysis of individual participant data examined whether subclinical hypo- or hyperthyroidism is associated with increased risk of cognitive decline and dementia.
Methodology
Pooled individual participant data from multiple international prospective cohorts with baseline thyroid function tests.
Key Findings
Subclinical thyroid dysfunction was not significantly associated with an increased risk of cognitive decline or dementia.
Conclusions
Subclinical thyroid dysfunction does not appear to be a significant independent risk factor for cognitive decline in older populations.
Limitations
Variation in thyroid function assay methods and cognitive assessment tools; residual confounding possible; relatively short follow-up in some cohorts.
Related Health Concerns
Study Details
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Disclosures
Funding
Swiss National Science Foundation and other national funding bodies
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