Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis
Cayzeele-Decherf A, Pelerin F, Leuillet S, Douillard B, Housez B, Cazaubiel M, Jacobson GK, Justen P, Desreumaux P
Published in World Journal of Gastroenterology
Key Findings
Pooled individual data from 579 IBS subjects showed improvement in abdominal pain/discomfort and bloating scores with S. cerevisiae CNCM I-3856 versus placebo, strongest in IBS-C.
Conclusions
A specific yeast probiotic reduces bloating in a subset of IBS patients.
Limitations
Both pooled trials industry-sponsored; single strain; modest effect sizes.
Supplements Studied
An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal (GI) symptoms in IBS subjects.
Outcomes Measured
Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating.
Study Details
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