Mood
    Limited

    Panic Attack Prevention

    Reduced frequency and intensity of panic episodes and acute anxiety.

    TL;DR

    Panic attacks respond best to CBT with interoceptive exposure — the single most effective intervention. Supplements play a minor supporting role; inositol has the only panic-specific trial data, and it is thin.

    Why It Matters

    Panic disorder involves a fear-of-fear cycle: bodily sensations get catastrophically misinterpreted, driving further arousal. This is why avoidance worsens it and why exposure-based CBT works. Medical mimics matter — thyroid disease, arrhythmia, anaemia and, rarely, phaeochromocytoma can present as panic and should be excluded once.

    How to Measure

    Biomarkers

    Panic attack frequency per week
    TSH
    Full blood count
    Resting heart rate and HRV
    Caffeine and alcohol intake

    Optimization Protocol

    1) Rule out thyroid, cardiac and anaemia mimics once. 2) CBT with interoceptive exposure is first-line and outperforms every other option. 3) Cut caffeine — it is a reliable panic trigger in susceptible people — and reduce alcohol, as rebound anxiety drives next-day attacks. 4) Practise slow nasal breathing with extended exhale daily, not just during attacks. 5) Adjuncts with any data: inositol 12-18g/day (small trials suggesting comparable effect to fluvoxamine, GI side effects common), magnesium 200-400mg/day, L-theanine 200mg for acute arousal. 6) SSRIs are effective and appropriate where attacks are frequent.

    Lifestyle Levers

    • Interoceptive exposure practice
    • Caffeine elimination
    • Alcohol reduction
    • Daily slow breathing practice
    • Regular aerobic exercise
    • Sleep regularity

    Supporting Supplements

    Supporting Research

    Frequently Asked Questions

    Typical Timeframe

    CBT reduces attack frequency within 8-12 weeks. Caffeine removal can help within days.

    Research Summary

    Studies8
    Supplements3
    Evidence
    Limited

    My Notes

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    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.