Glycation Prevention
Reduced advanced glycation end-product formation.
TL;DR
AGE formation tracks average blood sugar, so glycaemic control and cooking method matter most. Benfotiamine and carnosine have mechanistic support but limited hard outcome data.
Why It Matters
Advanced glycation end-products accumulate in collagen, arteries and the lens, contributing to arterial stiffening, cataract and diabetic complications. Tissue AGE burden reflects years of cumulative glycaemic exposure.
How to Measure
Biomarkers
Optimization Protocol
Prioritise glycaemic control: post-meal walking, resistance training, fibre before carbohydrate, and limiting refined sugar. Cook with moist low-heat methods, since grilling, frying and roasting create dietary AGEs. Benfotiamine 300 mg or carnosine 500-1000 mg may be trialled as adjuncts.
Supporting Supplements
Berberine
Lowering average glucose is the real mechanism, and berberine does that well.
L-Carnosine
Strong mechanistic case as a carbonyl scavenger, weak human outcome data.
Alpha Lipoic Acid (ALA)
Useful adjunct where glucose control and diabetic complications are the concern.
Supporting Research
Frequently Asked Questions
Typical Timeframe
3-6 months (HbA1c cycle)
Research Summary
My Notes
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.