Glutathione Enhancement
Increase in the body's master antioxidant, critical for detoxification, immune function, and cellular protection. Supported by NAC, selenium, and glutathione precursors.
TL;DR
Oral glutathione is largely broken down before absorption, so precursors work better. NAC and adequate selenium and glycine give the body what it needs to make its own.
Why It Matters
Glutathione is central to phase II detoxification, redox balance and immune function. Depletion occurs in paracetamol overdose, chronic liver disease, HIV and severe oxidative stress states, and is genuinely clinically significant in those settings.
How to Measure
Biomarkers
Optimization Protocol
Ensure adequate protein for cysteine and glycine, and correct selenium status, since glutathione peroxidase is selenium-dependent. NAC 600-1200 mg daily is the best-supported precursor. Cruciferous vegetables and reduced alcohol intake also help. Liposomal glutathione absorbs better than standard oral forms.
Supporting Supplements
N-Acetyl Cysteine (NAC)
The best-established way to raise glutathione, with decades of clinical use.
Selenium
Correcting selenium status matters for glutathione function, but only if you are low.
Glutathione
Standard oral glutathione absorbs poorly; liposomal forms do better but the evidence base is thin.
Supporting Research
Frequently Asked Questions
Typical Timeframe
4-8 weeks
Research Summary
My Notes
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.