Longevity & Healthy Aging
Extending healthspan, slowing biological aging, and optimizing vitality in later years.
Overview
Longevity science examines the biological mechanisms of aging including cellular senescence, telomere shortening, mitochondrial dysfunction, and epigenetic changes. While maximum lifespan is genetically constrained, healthspan - years lived in good health - is highly modifiable through lifestyle, nutrition, and emerging anti-aging interventions.
Why This Matters
Average lifespan has increased dramatically, but healthspan hasn't kept pace - many spend their final decades with chronic disease and disability. Emerging research on caloric restriction, NAD+ metabolism, senolytic compounds, and other interventions shows promise for extending not just life, but quality of life in later years.
Key Considerations
- •Only 25% of longevity is determined by genetics; 75% is lifestyle
- •Cellular senescence contributes to age-related disease and frailty
- •NAD+ levels decline 50% between ages 40-60, affecting energy and repair
- •Caloric restriction activates longevity pathways including AMPK and sirtuins
- •Inflammation (inflammaging) accelerates biological aging
- •Social connections and purpose strongly predict longevity
Topic Summary
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.