Vitamin E

The evidence is insufficient to recommend multivitamins for preventing cardiovascular disease or cancer, and beta-carotene and vitamin E are recommended against.

Large observational cohorts reported lower coronary heart disease rates among people with high vitamin E intake, but randomised trials of alpha-tocopherol supplementation, including HOPE and GISSI, found no reduction in cardiovascular events. High-dose supplementation showed signals of harm, including increased heart failure and haemorrhagic stroke risk in some trials.

Selenium 200 mcg/day did not prevent prostate cancer, and a non-significant increase in type 2 diabetes risk was observed in the selenium arm.

Fish oil, garlic, ginkgo, ginger, vitamin E and others show antiplatelet activity and can potentiate bleeding risk with anticoagulants.

Network meta-analysis of nutritional supplement trials in healthy older adults and people with mild cognitive impairment found omega-3 fatty acids and B-vitamin combinations ranked highest for global cognition and memory outcomes, while most single-nutrient interventions including vitamin E and standalone vitamin D showed no significant benefit versus placebo; effect sizes were small overall.

vitamin D and E vaginal suppositories were beneficial in improving vaginal atrophy

vaginal vitamin E may be effective in alleviating symptoms of genitourinary syndrome of menopause

the clinical magnitude of this reduction was marginal

Vitamin E has only marginal effect on vasomotor symptoms

oral intake of curcumin and vitamin E significantly reduced hot flashes

vitamin E suppositories could improve the laboratory criteria for vaginal atrophy

a vitamin E vaginal suppository may be an alternative to vaginal estrogen

combined vaginal cream of vitamins D and E is a suitable alternative to vaginal estrogens

One study assessing vitamin E did not show any beneficial effect

vitamin E reduced the incidence of hot flashes by nearly one-third of the base amount

vitamin E might be an effective measure to reduce SBP, but more research is needed to validate this finding

vitamin E increased the risk for haemorrhagic stroke by 22%

Administration of alpha-tocopherol acetate reduced vaginal mucosal inflammation

Serum levels of TAC significantly increased in curcumin and vitamin E groups

serum vitamin E predicted hemorrhagic events

showed no significant differences with the placebo

dryness, itching, and pain during intercourse, were resolved post-treatment

vitamin E can safely be given to patients who require chronic warfarin therapy

Compared to vitamin E, estrogen administration leads to better clinical effects

There were 579 cataracts in the vitamin E-treated group and 595 in the vitamin E placebo group (hazard ratio, 0.99; 95% confidence interval, 0.88-1.11).

High-dosage vitamin E supplementation (400 IU/day or more) may increase all-cause mortality.

Vitamin E supplementation significantly increased the risk of prostate cancer among healthy men.

Vitamin E supplementation significantly increased prostate cancer risk by 17%

The administration of Vit E had significant curative results.

antioxidant vitamins supplementation reduce endometriosis related pelvic pain in humans

Vitamins C and E and their combination are safe and effective treatments for reducing the severity of RLS in hemodialysis patients over the short-term.

High-dose vitamin E halted progression and improved some neurological signs in early-stage patients.

Subfertile couples should be advised that overall, the current evidence is inconclusive based on serious risk of bias.

No clinical benefit could be demonstrated from active treatment. There are several possible explanations for this negative result, including the short duration of therapy. It is possible that antioxidant therapy, to be effective, needs to be given early in the SSc disease process, before the onset of irreversible tissue damage.

Antioxidant supplementation, including vitamin E, was associated with improved pregnancy and live birth rates in subfertile men.

Vitamin E produced a small but statistically significant reduction in hot flush frequency and severity

the effect of vitamin E (as α-tocopherol) supplementation on colorectal adenoma occurrence considered as a secondary objective

Antioxidant vitamin supplementation prevents oxidative stress but does not enhance performance in young football athletes.

Antioxidant vitamin formulations including vitamin E slowed progression of age-related macular degeneration.

Short-term treatment with vit. E is safe and effective in reducing number of attacks of muscle cramps in HD patients, as shown in our study.

Antioxidants for female subfertility.

A high whey protein, vitamin D and E supplement preserved muscle mass and strength in sarcopenic older adults

In the active group, there was a large improvement of pain (PS from 20.9 to 13.9, p < 0.001).

Long-term vitamin E did not prevent cancer or major cardiovascular events and increased heart failure.

Antioxidant supplements did not reduce mortality; beta-carotene and vitamin E were associated with increased mortality

This study did not show significant improvement in pain, curvature or plaque size in patients with PD treated with vitamin E, propionyl-L-carnitine, or vitamin E plus propionyl-L-carnitine compared with those treated with placebo. Note: an Expression of Concern (PMID 36626346) was issued for this paper in 2023.

Supplemental vitamin E intake was non-significantly associated with ARC risk (relative risk=0.92; 95% CI 0.78, 1.07).

Antioxidant therapy in patients with OSA is associated with improved endothelial function, reduced oxidative stress, and improved sleep parameters.

The results showed that EPO has no difference to reduce breast pain compared to topical NSAIDS, danazol, or vitamin E.

The use of the anti-stretch mark product is proved to be effective in reducing severity of the striae during pregnancy, prevents the appearance of new striae and halts progression of those already present.

Overall, DOMS of the quadriceps was lower in S (1.1±0.3) than P (2.2±0.5) (P<0.05).

Without discriminating the number of antibiotics used, there was no relationship with the eradication of the infection (OR: 1.98 [95%CI: 0.92-4.29] P=.08).

Short-term high-dose vitamin C and E supplementation attenuates muscle damage, hemolysis, and inflammatory responses to repeated taekwondo competitions.

Vitamin E was superior to placebo for improving histological features of nonalcoholic steatohepatitis.

Sperm motility, morphology or both improved in 52.6% of treated men

Although vitamin C and E supplementation may attenuate exercise-induced increases in plasma IL-6 there is no clear additive effect when combined with endurance training.

Alpha-tocopherol 2000 IU/day slowed functional decline in mild to moderate Alzheimer disease.

Vitamin E could be an adjunctive treatment for women with PD. However, higher-quality clinical trials with larger sample sizes are recommended for a more definite conclusion.

Both vitamins and commercial supplements have low effectiveness in reducing DOMS, while polyphenols and other antioxidant supplements show moderate to good effectiveness in combating DOMS.

We can affirm that vitamin E can help to prevent the progression of PD. This study strongly supports the recommendation that the best approach for treating PD is multimodal therapy.

Neither vitamin E nor vitamin C reduced major cardiovascular events in male physicians.

Meta-analysis of randomized controlled trials evaluating antioxidant supplementation and auditory threshold change in sensorineural hearing loss.

Alpha-tocopherol supplementation did not reduce lung cancer incidence in male smokers.

An oral combination of vitamins A, C, E, and Mg++ improves auditory thresholds in age-related hearing loss.