NMN for Stem Cell Preservation
NMN raises NAD+ but no human data shows stem cell preservation.
Overview
Verdict
How It Works
Dosing & Protocol
Typical dose
- Recommended dose
- 250-500mg/day if trialled
- Expected timeframe
- Unknown
Protocol
- form
- Not applicable; regulatory status contested
- duration
- Not applicable
- co factor
- Evidence is insufficient. Mouse work provides the rationale: NAD+ decline has been linked to impaired mitochondrial unfolded protein response in muscle stem cells, and NAD+ precursor administration improved stem cell function and regenerative capacity in aged mice, including in muscle, intestinal and neural stem cell populations. That is genuinely interesting preclinical biology. It has not been tested in humans. Human NMN trials at 250-1,000 mg/day over 6-12 weeks measured blood NAD+, insulin sensitivity, aerobic capacity and walking speed. Assessing stem cell pools in living people requires tissue biopsy and specialised assays, so there is no human data on stem cell number, function or regenerative capacity with NMN, and no non-invasive way for an individual to assess it.
- titration
- Not applicable
- starting dose
- Not established
Evidence
What the studies say
NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice
Zhang H, Ryu D, Wu Y +4 more
NAD+ repletion rejuvenated muscle stem cells and extended lifespan in aged mice
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults
Martens CR, Denman BA, Mazzo MR +5 more
Nicotinamide riboside effectively doubled NAD+ levels and was well tolerated
Safety
Caveats
Extrapolated from rodent work. No human stem cell endpoints exist.
Less likely to help if
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