Condition
    Strong Evidence
    Effectiveness 3/5

    Black Cohosh for Menopause

    Black cohosh may modestly reduce hot flushes, but trial results conflict and liver safety signals require attention.

    Overview

    Black cohosh may modestly reduce hot flushes, but trial results conflict and liver safety signals require attention.

    Verdict

    Mixed evidence

    How It Works

    Black cohosh does not appear to act as a phytoestrogen; proposed actions include serotonergic 5-HT7 receptor modulation and central thermoregulatory effects.

    Dosing & Protocol

    Typical dose

    Recommended dose
    40-80mg standardized extract daily
    Expected timeframe
    4-12 weeks

    Protocol

    form
    Extract standardised to 2.5% triterpene glycosides, third-party tested
    step 1
    Decide what you are treating - black cohosh has data only for vasomotor symptoms, not for bone loss, genitourinary symptoms or cardiovascular risk, all of which need separate management
    timing
    With food
    duration
    Review at 12 weeks; do not continue beyond 6-12 months without medical review
    titration
    Increase to 40-80 mg/day after two weeks if flushes persist
    measurement
    A symptom diary of flush frequency and severity across a full week, before and at week 12
    starting dose
    20-40 mg standardised extract daily with food

    Evidence

    What the studies say

    A Cochrane review found insufficient evidence for a consistent effect on vasomotor symptoms, while some individual trials of standardised extracts reported reductions versus placebo. Rare idiosyncratic hepatotoxicity has prompted regulatory warnings in several countries.

    Black cohosh (Cimicifuga spp.) for menopausal symptoms

    Score: 9/10
    2012
    meta_analysis
    n=2027

    Leach MJ, Moore V

    There was no significant difference between black cohosh and placebo in the frequency of hot flushes or in menopausal symptom scores across the pooled trials.

    View source

    Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial

    Score: 9/10
    2006
    rct
    n=351

    Newton KM, Reed SD, LaCroix AZ +3 more

    Black cohosh, multibotanical preparations and soy did not reduce vasomotor symptom frequency or intensity more than placebo at any timepoint, whereas hormone therapy did.

    View source

    Safety

    Caveats

    A Cochrane review found insufficient evidence for a consistent effect on vasomotor symptoms, though some standardised-extract trials are positive - expect a modest and uncertain benefit. It does nothing for the bone loss that accelerates at menopause, so do not let it substitute for that conversation. Rare but serious hepatotoxicity including liver failure has been reported: stop at once with jaundice, dark urine, abdominal pain or unusual fatigue, and avoid in liver disease. Contraindicated in pregnancy and breastfeeding. Discuss with your oncologist in breast or hormone-sensitive cancer, and note possible tamoxifen interaction. Menopausal hormone therapy is more effective for moderate to severe symptoms.

    Less likely to help if

    Women with severe symptoms needing hormone therapy, and those whose main issues are genitourinary or bone-related.

    Medical Disclaimer

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    Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.