Vitamins and Minerals for Migraine Prophylaxis: A Systematic Review and Meta-analysis
Okoli GN, Rabbani R, Kashani HH
Published in Canadian Journal of Neurological Sciences
Methodology
Systematic review and meta-analysis of 18 placebo-controlled randomized trials of vitamins and minerals for migraine prophylaxis; only CoQ10 and magnesium had poolable data.
Key Findings
In adults, CoQ10 did not significantly reduce migraine frequency (MD -0.44, 95% CI -2.14 to 1.26), duration or severity; magnesium did not significantly reduce migraine severity (RoM -0.17, 95% CI -0.36 to 0.02).
Conclusions
Evidence for vitamins and minerals in migraine prophylaxis is limited and largely non-significant; larger high-quality trials are needed.
Limitations
Few poolable trials, small samples (under 250 participants per comparison), heterogeneity, low to moderate strength of evidence.
Supplements Studied
Magnesium did not significantly decrease migraine severity (RoM -0.17 (-0.36 to 0.02)).
In adults, compared with placebo, coenzyme Q10 did not significantly decrease migraine frequency (mean difference (MD) -0.44 (-2.14 to 1.26)).
Pooled estimates favoured riboflavin for reducing migraine days, with low to moderate certainty of evidence.
Outcomes Measured
Pooled data favoured riboflavin for reducing migraine days.
In adults, compared with placebo, coenzyme Q10 did not significantly decrease migraine frequency (mean difference (MD) -0.44 (-2.14 to 1.26)).
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.