Vitamin D controls T cell antigen receptor signaling and activation of human T cells
von Essen MR, Kongsbak M, Schjerling P, Olgaard K, Odum N, Geisler C
Published in Nature Immunology, Vol. 11 (4), pp. 344-9
Methodology
Mechanistic human immunology study of vitamin D receptor and phospholipase C-gamma1 signalling in naive T cells exposed to varying vitamin D levels.
Key Findings
Naive T cells failed to activate without vitamin D, which was required to induce phospholipase C-gamma1 and antigen receptor signalling.
Conclusions
Vitamin D sufficiency is a prerequisite for T-cell activation.
Limitations
Ex vivo human cells; no clinical outcome measured.
Supplements Studied
Naive T cells failed to activate without vitamin D, which was required to induce antigen receptor signalling
Outcomes Measured
Naive T cells failed to activate without vitamin D, which was required to induce phospholipase C-gamma1 and antigen receptor signalling
Study Details
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