Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism
Patrick RP, Ames BN
Published in FASEB Journal, Vol. 28 (6), pp. 2398-413
Methodology
Review of molecular and observational evidence linking vitamin D hormone response elements to serotonin and oxytocin gene regulation.
Key Findings
Vitamin D response elements were identified in the oxytocin gene promoter, suggesting transcriptional regulation of oxytocin by vitamin D.
Conclusions
Vitamin D adequacy may support endogenous oxytocin signalling.
Limitations
Mechanistic and observational only; no human supplementation trial of oxytocin output.
Supplements Studied
Vitamin D response elements were identified in the oxytocin gene promoter
Outcomes Measured
Vitamin D response elements were identified in the oxytocin gene promoter, suggesting transcriptional regulation of oxytocin by vitamin D
Study Details
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