The Effect of Vitamin C Supplements on Urinary Stone Risk: A Systematic Review and Meta-Analysis
Farkouh A, Seibly E, Buell MI, Jhang D, Amasyali AS, Okhunov Z, et al.
Published in J Endourol, Vol. 40 (11), pp. 1242-1253
Methodology
Systematic review and meta-analysis of 9 interventional studies (1965 to February 2023) measuring 24-hour urine oxalate, citrate and calcium with vitamin C supplements in stone formers and non-stone formers.
Key Findings
Vitamin C raised urine oxalate versus baseline (mean difference 9.72 mg/24 h, p < 0.001) and versus placebo (6.45 mg/24 h, p < 0.001), in both stone formers and non-formers. No significant effect on urine citrate or calcium.
Conclusions
Vitamin C supplements significantly increase urinary oxalate excretion, which may contribute to stone formation.
Limitations
Small, short studies; urine markers, not stone events.
Supplements Studied
Vitamin C supplements significantly increase urinary oxalate excretion in both SFs and NSFs
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.