Remedy Routes
    systematic_review
    2005

    Treatment of hyperlipoproteinemia with pantethine: a review and analysis of efficacy and tolerability

    McRae MP

    Published in Nutrition Research, Vol. 25 (4), pp. 319-333

    Methodology

    Pooled analysis of 28 trials with 646 participants receiving pantethine for hyperlipoproteinemia.

    Key Findings

    Average reductions of about 14% in total cholesterol, 20% in LDL and 33% in triglycerides, with HDL rising about 8%; tolerability was good.

    Conclusions

    Pantethine appears effective and well tolerated for dyslipidemia, though most included trials were old and small.

    Limitations

    Largely older, small, non-blinded Italian trials; high risk of publication bias.

    Supplements Studied

    Vitamin B5
    Vitamin

    Pantethine produced average reductions of about 14% in total cholesterol and 20% in LDL cholesterol across 28 trials.

    Outcomes Measured

    HDL Cholesterol Increase

    HDL cholesterol rose approximately 8% with pantethine treatment.

    Cholesterol Management
    Primary

    Pantethine reduced total cholesterol, LDL and triglycerides with an 8% rise in HDL.

    Related Health Concerns

    High Cholesterol (Dyslipidemia)

    Study Details

    Year:2005
    Sample Size:646
    Duration:16 weeks
    Quality Score:4/10

    Access Study

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