Remedy Routes
    rct
    2002
    High Quality

    Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein: a potential link to fatty acid-induced insulin resistance

    Risérus U, Basu S, Jovinge S, Fredrikson GN, Arnlöv J, Vessby B

    Published in Circulation, Vol. 106 (15), pp. 1925-9

    Methodology

    Double-blind placebo-controlled trial in 60 men with metabolic syndrome: trans-10,cis-12 CLA, a CLA mixture or placebo for 12 weeks. Insulin sensitivity by euglycaemic clamp.

    Key Findings

    Trans-10,cis-12 CLA raised urinary 8-iso-PGF2alpha (an oxidative-stress marker) by 578% and C-reactive protein by 110% versus placebo. The rise in oxidative stress was independently related to worsening insulin resistance.

    Conclusions

    The trans-10,cis-12 isomer increases oxidative stress and inflammatory markers in obese men, closely tied to induced insulin resistance.

    Limitations

    Men only; 12 weeks; surrogate markers rather than clinical events.

    Supplements Studied

    t10c12 CLA supplementation increases oxidative stress and inflammatory biomarkers in obese men

    Outcomes Measured

    Insulin Sensitivity
    Primary

    closely related to induced insulin resistance

    Related Health Concerns

    Metabolic Syndrome
    Obesity

    Study Details

    Year:2002
    Sample Size:60
    Duration:12 weeks
    Quality Score:7/10

    Access Study

    View on DOIView on PubMedOriginal Source

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.