Statin therapy and plasma coenzyme Q10 concentrations--A systematic review and meta-analysis of placebo-controlled trials
Banach M, Serban C, Ursoniu S, Rysz J, Muntner P, Toth PP, et al.
Published in Pharmacol Res, Vol. 99, pp. 329-36
Methodology
Systematic review and meta-analysis of placebo-controlled randomised trials measuring plasma CoQ10 during statin therapy, searched to April 2015.
Key Findings
Data from 8 placebo-controlled treatment arms showed statins lowered plasma CoQ10 by 0.44 µmol/L (95% CI -0.52 to -0.37, p < 0.001), consistently across atorvastatin, simvastatin, rosuvastatin and pravastatin.
Conclusions
Statins significantly reduce plasma CoQ10; the clinical relevance needs further trials.
Limitations
Measures a blood level, not a clinical outcome; few trial arms.
Supplements Studied
a significant reduction in plasma CoQ10 concentrations following treatment with statins
Study Details
Access Study
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.