An increase in selenium intake improves immune function and poliovirus handling in adults with marginal selenium status
Broome CS, McArdle F, Kyle JA, Andrews F, Lowe NM, Hart CA, Arthur JR, Jackson MJ
Published in American Journal of Clinical Nutrition, Vol. 80 (1), pp. 154-62
Methodology
Randomized placebo-controlled trial of selenium 50 or 100 mcg/day in adults with marginal selenium status, challenged with live attenuated poliovirus.
Key Findings
Selenium supplementation increased T-cell proliferation and accelerated poliovirus clearance compared with placebo.
Conclusions
Correcting marginal selenium status improves cellular immunity.
Limitations
Small sample; marginal-status population only.
Supplements Studied
Selenium supplementation increased T-cell proliferation and accelerated poliovirus clearance compared with placebo
Outcomes Measured
Selenium supplementation increased T-cell proliferation and accelerated poliovirus clearance compared with placebo
Study Details
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