Safety of calcium and vitamin D supplements, a randomized controlled trial
Aloia JF, Katumuluwa S, Stolberg A, Usera G, Mikhail M, Hoofnagle AN, et al.
Published in Clin Endocrinol (Oxf), Vol. 89 (6), pp. 742-749
Methodology
One-year RCT in healthy white postmenopausal women, all taking calcium carbonate 1,200 mg/day, randomised to vitamin D3 10,000 IU/day or 600 IU/day, with serum and 24-hour urine calcium every 3 months.
Key Findings
Hypercalciuria and hypercalcaemia occurred in both groups. At the final visit, 19 of 48 women in the high-dose group had hypercalciuria; the odds of hypercalciuria were 3.6 times higher with 10,000 IU (OR 3.6, 95% CI 1.39 to 9.3). The odds of hypercalcaemia did not differ.
Conclusions
10,000 IU/day of vitamin D taken with calcium supplements results in frequent hypercalciuria; its effect on stones needs study.
Limitations
Urine and blood markers only, not stones; one year; white postmenopausal women only.
Supplements Studied
results in frequent hypercalciuria
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.