Recruited brown adipose tissue as an antiobesity agent in humans
Yoneshiro T, Aita S, Matsushita M, Kayahara T, Kameya T, Kawai Y, Iwanaga T, Saito M
Published in Journal of Clinical Investigation
Methodology
Six-week cold acclimation and capsinoid ingestion with FDG-PET/CT quantification of brown adipose tissue
Key Findings
Daily ingestion of capsinoids over 6 weeks recruited brown adipose tissue activity and increased cold-induced energy expenditure in adults with previously undetectable BAT.
Conclusions
Capsinoids can activate and recruit thermogenic brown/beige fat in humans.
Limitations
Short duration; surrogate imaging endpoints; no body-composition change demonstrated.
Supplements Studied
Daily ingestion of capsinoids for 6 weeks increased CIT, demonstrating that human BAT can be recruited by dietary thermogenic compounds.
Outcomes Measured
Daily ingestion of capsinoids over 6 weeks recruited brown adipose tissue activity and increased cold-induced energy expenditure.
Daily ingestion of capsinoids for 6 weeks increased CIT. Human BAT can be recruited even in individuals with decreased BAT activity.
Study Details
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Disclosures
Funding
Japanese government grants
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