Propionyl-L-carnitine for intermittent claudication
Kamoen V, Vander Stichele R, Campens L, De Bacquer D
Published in Cochrane Database of Systematic Reviews
Methodology
Cochrane systematic review and meta-analysis of randomized trials comparing propionyl-L-carnitine with placebo or other treatments for pain-free and maximum walking distance in stable Fontaine stage II intermittent claudication.
Key Findings
Propionyl-L-carnitine showed modest improvements in walking distance versus placebo, but the evidence base was limited and largely industry-sponsored.
Conclusions
Evidence for propionyl-L-carnitine in intermittent claudication is of low certainty and not sufficient to recommend routine use.
Limitations
Few trials, industry sponsorship, heterogeneous treadmill protocols.
Supplements Studied
Low-certainty evidence suggests propionyl-L-carnitine may improve maximum walking distance compared with placebo.
Related Health Concerns
Study Details
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Disclosures
Funding
Cochrane / non-commercial support
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