Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators
Serhan CN, Levy BD
Published in Journal of Clinical Investigation, Vol. 128 (7), pp. 2657-2669
Methodology
Review of human and translational evidence on omega-3-derived resolvins and protectins acting on macrophage efferocytosis and inflammation resolution.
Key Findings
Omega-3-derived mediators enhance macrophage clearance of apoptotic cells and shift macrophages toward a resolving phenotype.
Conclusions
Marine omega-3s provide substrate for pro-resolving mediators acting on macrophages.
Limitations
Largely mechanistic and translational; few randomized clinical endpoints.
Supplements Studied
Omega-3-derived mediators enhance macrophage clearance of apoptotic cells
Outcomes Measured
Omega-3-derived mediators enhance macrophage clearance of apoptotic cells and shift macrophages toward a resolving phenotype
Study Details
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