Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults
Smith GI, Julliand S, Reeds DN, Sinacore DR, Klein S, Mittendorfer B
Published in American Journal of Clinical Nutrition, Vol. 102 (1), pp. 115-22
Methodology
Randomized controlled trial of fish oil-derived omega-3 supplementation in older adults with muscle biopsies measuring anabolic signalling, muscle mass and strength.
Key Findings
Omega-3 supplementation increased thigh muscle volume and handgrip strength, with enhanced mTOR-related anabolic signalling responses.
Conclusions
Omega-3 fatty acids sensitise muscle mTOR signalling to anabolic stimuli in older adults.
Limitations
Modest sample; older adults only; mechanistic markers secondary.
Supplements Studied
Omega-3 supplementation increased thigh muscle volume and handgrip strength in older adults
Outcomes Measured
Omega-3 supplementation increased thigh muscle volume and handgrip strength, with enhanced mTOR-related anabolic signalling responses
Omega-3 supplementation increased thigh muscle volume and handgrip strength, with enhanced mTOR-related anabolic signalling responses.
Study Details
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