Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications
Bays HE, Tighe AP, Sadovsky R, Davidson MH
Published in Expert Review of Cardiovascular Therapy, Vol. 6 (3), pp. 391-409
Methodology
Review of randomized trials measuring lipoprotein subfractions after marine omega-3 supplementation in hypertriglyceridaemic adults.
Key Findings
Omega-3 supplementation shifted LDL toward larger, more buoyant particles while lowering triglycerides, though total LDL cholesterol sometimes rose.
Conclusions
Marine omega-3s improve LDL particle size distribution mainly by lowering triglyceride-rich lipoproteins.
Limitations
Subfraction measurement methods differ between trials; clinical significance of particle size shift remains debated.
Supplements Studied
Omega-3 supplementation shifted LDL toward larger, more buoyant particles while lowering triglycerides
Outcomes Measured
Omega-3 supplementation shifted LDL toward larger, more buoyant particles while lowering triglycerides
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.