Novel Chewable Pleuran-Based Supplement Decreases Respiratory Tract Infections in Children: A Randomised Controlled Trial

Jesenak M, Prokopova E, Bozensky J, Bonaci-Nikolic B, Milosevic K, Stankovic K, et al.

Published in Adv Ther, Vol. 42 (12), pp. 6132-6149

Methodology

Double-blind, placebo-controlled, randomised multicentre trial in 249 children with recurrent respiratory infections in Slovakia, the Czech Republic and Serbia. Children took a chewable pleuran supplement with vitamin D and zinc, or vitamin D and zinc alone, for 3 months between October and March; 217 completed.

Key Findings

Total respiratory infections were 15.2% lower with pleuran (2.35 vs 2.77; P=0.042) and common colds 18.6% lower (1.53 vs 1.88; P=0.040). Effects were clearer in children over 6 and appeared after the first month, and tonsillopharyngitis was less frequent and shorter. Compliance was 98.7% with only mild adverse events.

Conclusions

The authors concluded that the chewable pleuran supplement reduced respiratory infections in children with recurrent infections, with a quick onset and good safety.