Impact of a non-fluoridated microcrystalline hydroxyapatite dentifrice on enamel caries progression in highly caries-susceptible orthodontic patients: A randomized, controlled 6-month trial
Schlagenhauf U, Kunzelmann KH, Hannig C, May TW, Hösl H, Gratza M, et al.
Published in J Investig Clin Dent, Vol. 10 (2), pp. e12399
Methodology
Randomized controlled trial in 150 highly caries-active orthodontic patients: fluoride-free microcrystalline hydroxyapatite toothpaste versus 1400 ppm fluoride toothpaste for 168 days after bracket fixation; primary outcome new enamel caries (ICDAS code 1 or above).
Key Findings
Enamel caries increased in 56.8% (intention-to-treat) of the hydroxyapatite group and 60.9% of the fluoride group; non-inferiority testing showed no significant difference, and secondary outcomes did not differ.
Conclusions
In highly caries-active patients, regular microcrystalline hydroxyapatite toothpaste did not differ significantly from 1400 ppm fluoride toothpaste for caries progression.
Limitations
Six months; orthodontic patients only; over half of both groups developed new lesions.
Supplements Studied
not significantly different from the use of a 1400 ppm fluoride toothpaste
Related Health Concerns
Study Details
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