No association between the common MTHFR 677C->T polymorphism and venous thrombosis: results from the MEGA study
Bezemer ID, Doggen CJ, Vos HL, Rosendaal FR
Published in Arch Intern Med, Vol. 167 (5), pp. 497-501
Methodology
MEGA population-based case-control study in the Netherlands: DNA from 4,375 patients with a first deep vein thrombosis or pulmonary embolism and 4,856 controls, with questionnaire data on other risk factors.
Key Findings
C677T was not associated with venous thrombosis: OR 0.99 (0.91-1.08) for CT and 0.94 (0.81-1.08) for TT, with no association in any risk-factor subgroup.
Conclusions
Mildly raised homocysteine from MTHFR TT does not appear to cause venous thrombosis, and there is no clinical rationale for measuring the variant.
Limitations
Case-control design; single country.
Related Health Concerns
Study Details
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