NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice
Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, Auwerx J
Published in Science, Vol. 352 (6292), pp. 1436-43
Methodology
Preclinical mechanistic studies of NAD+ repletion on mitochondrial unfolded protein response and muscle stem cell function in aged mice, reviewed alongside early human data.
Key Findings
NAD+ repletion rejuvenated muscle stem cells and extended lifespan in aged mice via mitochondrial quality control.
Conclusions
NAD+ precursors preserve stem cell function in animals; human evidence pending.
Limitations
Animal data; no human stem-cell endpoints.
Supplements Studied
NAD+ repletion rejuvenated muscle stem cells and extended lifespan in aged mice
NAD+ repletion rejuvenated muscle stem cells and extended lifespan in aged mice via mitochondrial quality control.
Outcomes Measured
NAD+ repletion rejuvenated muscle stem cells and extended lifespan in aged mice via mitochondrial quality control
NAD+ repletion rejuvenated muscle stem cells and extended lifespan in aged mice via mitochondrial quality control
Study Details
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