Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures
Elhassan YS, Kluckova K, Fletcher RS, Schmidt MS, Garten A, Doig CL, et al.
Published in Cell Rep, Vol. 28 (7), pp. 1717-1728.e6
Methodology
Placebo-controlled, randomised, double-blind crossover trial in 12 older men taking 1 g nicotinamide riboside daily for 21 days, with muscle biopsies.
Key Findings
NR raised the muscle NAD+ metabolome (NAAD and nicotinamide clearance products) and lowered circulating inflammatory cytokines. Muscle RNA sequencing showed downregulated energy-metabolism and mitochondrial pathways, without any change in mitochondrial bioenergetics.
Conclusions
Oral NR reaches aged human muscle and has anti-inflammatory effects, but did not change mitochondrial function.
Limitations
Twelve men; three weeks; mechanistic outcomes only.
Supplements Studied
NR elevated the muscle NAD+ metabolome
Study Details
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