NAD⁺ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence
Gallagher C, Emmanuel OO
Published in Ageing Res Rev, Vol. 116, pp. 103057
Methodology
PRISMA-guided systematic review of human and rodent intervention studies (January 2010 to October 2025) of NAD-related compounds given orally or parenterally: 113 studies, including 33 human intervention studies (28 randomised).
Key Findings
In humans, oral NR and NMN consistently raised circulating or cellular NAD-related metabolites and were generally well tolerated over weeks to months, but effects on functional, metabolic, vascular and other healthspan outcomes were heterogeneous and often null. No eligible outcome trial evaluated intravenous or intramuscular NAD+ itself.
Conclusions
NAD+ augmentation has clear biological activity, but clinical effectiveness for anti-ageing or wellness outcomes remains inconclusive.
Limitations
Mixed study designs and endpoints prevented pooling; most human trials were small and short.
Supplements Studied
clinical effectiveness for anti-aging or wellness outcomes remains inconclusive
Outcomes Measured
oral NR and NMN consistently demonstrated biochemical target engagement
Study Details
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