Remedy Routes
    systematic_review
    2007

    Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose-effects: a review

    Sadowska AM, Manuel-Y-Keenoy B, De Backer WA

    Published in Pulmonary Pharmacology and Therapeutics, Vol. 20 (1), pp. 9-22

    Methodology

    Systematic review of clinical trials of N-acetylcysteine measuring glutathione status, lipid peroxidation and inflammatory oxidative markers.

    Key Findings

    NAC consistently restored glutathione levels and lowered markers of lipid peroxidation and oxidative injury.

    Conclusions

    NAC supports repair of oxidative damage by replenishing glutathione substrate.

    Limitations

    Heterogeneous patient groups and biomarker panels.

    Supplements Studied

    NAC consistently restored glutathione levels and lowered markers of lipid peroxidation

    Glutathione
    Compound

    NAC consistently restored glutathione levels and lowered markers of lipid peroxidation and oxidative injury.

    Outcomes Measured

    Oxidative Damage Repair

    NAC consistently restored glutathione levels and lowered markers of lipid peroxidation and oxidative injury

    Study Details

    Year:2007
    Duration:12 weeks
    Quality Score:6/10

    Access Study

    View on DOIView on PubMedOriginal Source

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