The proteostasis network and its decline in ageing
Hipp MS, Kasturi P, Hartl FU
Published in Nature Reviews Molecular Cell Biology, Vol. 20 (7), pp. 421-435
Methodology
Comprehensive mechanistic review of the cellular proteostasis network, chaperone function and pharmacological chaperone-inducing strategies.
Key Findings
Heat shock protein induction and chemical chaperones such as trehalose and 4-phenylbutyrate improve protein folding capacity in preclinical models.
Conclusions
Protein folding support is well established mechanistically but largely preclinical.
Limitations
No human supplement trials; mechanistic evidence only.
Outcomes Measured
Heat shock protein induction and chemical chaperones such as trehalose and 4-phenylbutyrate improve protein folding capacity in preclinical models
Study Details
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