meta_analysis
2018
High Quality
Efficacy of micronized purified flavonoid fraction (Daflon®) on improving individual symptoms, signs and quality of life in patients with chronic venous disease: a systematic review and meta-analysis of randomized double-blind placebo-controlled trials
Kakkos SK, Nicolaides AN
Published in International Angiology, Vol. 37 (2), pp. 143-154
Methodology
Meta-analysis of randomized trials of diosmin-hesperidin flavonoid fraction on venous symptoms, oedema and quality of life.
Key Findings
Flavonoid fraction significantly reduced leg oedema, heaviness, cramps and improved quality of life versus placebo or control.
Conclusions
Diosmin-based flavonoids improve venous return symptoms.
Limitations
Industry-sponsored trials predominate.
Outcomes Measured
Flavonoid fraction significantly reduced leg oedema, heaviness, cramps and improved quality of life versus placebo
Study Details
Year:2018
Duration:24 weeks
Quality Score:7/10
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