Fish oil (n-3 fatty acids) in drug resistant epilepsy: a randomised placebo-controlled crossover study

DeGiorgio CM, Miller PR, Harper R, Gornbein J, Schrader L, Soss J, Meymandi S

Published in Journal of Neurology, Neurosurgery & Psychiatry, Vol. 86 (1), pp. 65-70

Key Findings

Low-dose (1080 mg/day) omega-3 reduced seizure frequency by 33.6 percent versus placebo, while high-dose showed no benefit.

Any antiseizure effect of omega-3 appears dose-dependent and modest at best.

Small crossover trial, inconsistent dose-response.

Fatty Acid

Low-dose omega-3 reduced seizure frequency by 33.6 percent compared with placebo, whereas high-dose did not.

Year:2015

Sample Size:24

Duration:42 weeks

Quality Score:6/10

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