Low dose depot oral vitamin D3v. daily oral vitamin D3 for treating nutritional rickets: a randomised clinical trial
Saluja RK, Dewan P, Gomber S, Madhu SV, Bhat S, Gupta P
Published in Br J Nutr, Vol. 127 (12), pp. 1778-1783
Methodology
Randomised trial in 66 children aged 3 months to 5 years with nutritional rickets in Delhi. One group had daily oral vitamin D3 (2,000 IU for ages 3 to 12 months, 4,000 IU above 12 months) for 12 weeks; the other had a single oral depot dose (60,000 IU or 150,000 IU by age).
Key Findings
At 12 weeks 31 of 33 children (93.9%) in each group had radiological healing, and mean 25-hydroxyvitamin D was similar (120.2 versus 108 nmol/L, P = 0.43).
Conclusions
Low dose oral depot vitamin D3 is an effective alternative to daily oral vitamin D3 for nutritional rickets.
Limitations
Small, single-centre, 12 weeks of follow-up; the abstract does not say whether it was blinded.
Supplements Studied
Low dose oral depot vitamin D3 is an effective alternative to daily oral vitamin D3
Related Health Concerns
Study Details
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