The efficacy of long-term conjugated linoleic acid (CLA) supplementation on body composition in overweight and obese individuals: a systematic review and meta-analysis of randomized clinical trials
Onakpoya IJ, Posadzki PP, Watson LK, Davies LA, Ernst E
Published in Eur J Nutr, Vol. 51 (2), pp. 127-34
Methodology
Systematic review and meta-analysis of randomised trials lasting at least 6 months in overweight and obese people; 7 of 15 identified RCTs included.
Key Findings
CLA versus placebo: weight -0.70 kg (95% CI -1.09 to -0.32) and fat -1.33 kg (95% CI -1.79 to -0.86; I2 54%). Four of the seven trials had serious flaws in reporting their methods. Adverse events included constipation, diarrhoea and soft stools.
Conclusions
RCTs do not convincingly show any clinically relevant long-term effect of CLA on body composition.
Limitations
Few trials, four with serious reporting flaws; moderate heterogeneity.
Supplements Studied
the clinical relevance is uncertain
Outcomes Measured
does not convincingly show that CLA intake generates any clinically relevant effects
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.