Liver Injury Associated with Turmeric-A Growing Problem: Ten Cases from the Drug-Induced Liver Injury Network [DILIN]
Halegoua-DeMarzio D, Navarro V, Ahmad J, Avula B, Barnhart H, Barritt AS, et al.
Published in Am J Med, Vol. 136 (2), pp. 200-206
Methodology
Case series of all adjudicated cases in the US Drug-Induced Liver Injury Network (2004-2022) in which turmeric was an implicated product, with chemical analysis of products and HLA genotyping.
Key Findings
Ten cases, all since 2011 and 6 since 2017; injury was hepatocellular in 9. Five people were hospitalised and 1 died of acute liver failure. Turmeric was confirmed in all 7 products tested, 3 of which also contained piperine. Seven people carried HLA-B*35:01. Latency was 1-4 months.
Conclusions
Turmeric can cause potentially severe, typically hepatocellular liver injury, and reported cases appear to be increasing in the United States.
Limitations
Case series without a denominator, so it cannot estimate how common liver injury is.
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