Lack of effect of tart cherry concentrate dose on serum urate in people with gout
Stamp LK, Chapman P, Frampton C, Duffull SB, Drake J, Zhang Y, et al.
Published in Rheumatology (Oxford), Vol. 59 (9), pp. 2374-2380
Methodology
Randomized dose-ranging trial in 50 people with gout and serum urate above 0.36 mmol/L (half on allopurinol) given placebo or 7.5, 15, 22.5 or 30 mL tart cherry concentrate twice daily for 28 days.
Key Findings
No dose changed the serum urate area under the curve, urine urate excretion or gout flare frequency (P = 0.76). One of 24 adverse events (high blood sugar) was judged possibly related to the concentrate.
Conclusions
Tart cherry concentrate had no effect on serum urate or urine urate excretion; any effect on flares is unlikely to work through urate.
Limitations
Four weeks is short for flare outcomes; ten people per arm.
Supplements Studied
Tart cherry concentrate had no effect on SU or urine urate excretion
Related Health Concerns
Study Details
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