Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans
Wall BT, Stephens FB, Constantin-Teodosiu D, Marimuthu K, Macdonald IA, Greenhaff PL
Published in Journal of Physiology, Vol. 589 (Pt 4), pp. 963-73
Methodology
Randomized controlled trial of chronic carnitine plus carbohydrate feeding with muscle biopsies assessing carnitine content and substrate use.
Key Findings
Carnitine feeding raised muscle carnitine content and altered fuel selection, sparing glycogen at low intensity and increasing work output.
Conclusions
Raising muscle carnitine improves substrate switching between fat and carbohydrate.
Limitations
Requires high carbohydrate co-ingestion and 12+ weeks; small sample.
Supplements Studied
Carnitine feeding raised muscle carnitine content and altered fuel selection
Outcomes Measured
Carnitine feeding raised muscle carnitine content and altered fuel selection, sparing glycogen at low intensity
Study Details
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