Association of High-Dose Vitamin D Supplementation During Pregnancy With the Risk of Enamel Defects in Offspring: A 6-Year Follow-up of a Randomized Clinical Trial
Nørrisgaard PE, Haubek D, Kühnisch J, Chawes BL, Stokholm J, Bønnelykke K, et al.
Published in JAMA Pediatr, Vol. 173 (10), pp. 924-930
Methodology
Post hoc analysis of the double-blind COPSAC2010 randomized trial: pregnant women took high-dose vitamin D3 (2,400 IU a day) or placebo from week 24 of pregnancy to 1 week after birth, and all also received 400 IU a day. Dental examination at age 6 in 496 of 588 children.
Key Findings
Enamel defects in the permanent dentition were less common with high-dose vitamin D (15.1% versus 27.5%; odds ratio 0.47, 95% CI 0.27-0.81) and in the deciduous dentition (8.6% versus 15.9%; odds ratio 0.50, 95% CI 0.28-0.87). There was no association between supplementation and caries.
Conclusions
High-dose vitamin D in pregnancy was associated with about 50% lower odds of enamel defects in offspring; caries was not reduced.
Limitations
Dental outcomes were a post hoc analysis of a trial designed for asthma, 16% of children were not examined, and caries, the outcome this page is about, did not differ.
Supplements Studied
approximately 50% reduced odds of enamel defects in the offspring
Related Health Concerns
Study Details
Access Study
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.